SharePREDICTION OF LOCAL COOLING RATES AND CELL SURVIVAL DURING THE FREEZING OF A CYLINDRICAL SPECIMEN.
Author(s) : HAYES L. J.
Type of article: Article
Summary
A FINITE ELEMENT NUMERICAL MODEL WAS IMPLEMENTED TO SIMULATE THE FREEZING PROCESS OF AN AQUEOUS SALT SOLUTION IN A CYLINDRICAL CONTAINER. CHARACTERISTIC CELL SURVIVAL SIGNATURES WERE USED TO PREDICT THE ASSOCIATED LOCAL SURVIVAL RATES THROUGHOUT THE SYSTEM. THE CALCULATIONS SHOW THAT THERE ARE TWO DEFINITE TIME DOMAINS: (1) WHILE THE SURFACE TEMPERATURE IS CHANGING ; AND (2)AFTER THE SURFACE TEMPERATURE REACHES A CONSTANT STORAGE VALUE. THEY ALSO SHOW SIGNIFICANT SPATIAL VARIATIONS IN THE LOCAL COOLING RATES AND CONSIDERABLE LOCAL DEVIATION FROM THE VOLUMETRIC AVERAGE SURVIVAL FOR VARIOUS SIMULATED FREEZINGPROTOCOLS.
Details
- Original title: PREDICTION OF LOCAL COOLING RATES AND CELL SURVIVAL DURING THE FREEZING OF A CYLINDRICAL SPECIMEN.
- Record ID : 1989-0339
- Languages: English
- Source: Cryobiology - vol. 25 - n. 1
- Publication date: 1988
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