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Proton NMR studies on the permeation of tissue fragments by dimethyl sulphoxide: liver as a model for compact tissues.

Author(s) : FULLER B. J., BUSZA A. L.

Type of article: Article

Summary

Data on the permeability of liver tissue to the cryoprotective agent DMSO by diffusion have been obtained non-invasively using 1H nuclear magnetic resonance (NMR) spectroscopy during both exposure and washout. Results demonstrate that in compact tissues, equilibration with tissue water is not complete for up to 2 hours, while the kinetics for influx and efflux were similar. These observations are discussed in relation to the development of protocols for cryoprotectant exposure in tissue cryopreservation.

Details

  • Original title: Proton NMR studies on the permeation of tissue fragments by dimethyl sulphoxide: liver as a model for compact tissues.
  • Record ID : 1995-0578
  • Languages: English
  • Source: Cryo-Letters - vol. 15 - n. 2
  • Publication date: 1994/03
  • Document available for consultation in the library of the IIR headquarters only.

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