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SUCCESSFUL TRANSFUSION OF PLATELETS CRYOPRESERVED FOR MORE THAN 3 YEARS.

Author(s) : DALY P. A.

Type of article: Article

Summary

14 TRANSFUSIONS OF RANDOOM-DONOR, POOLED PLATELETS, STORED FOR A MEAN PERIOD OF 1,157 DAYS WERE ANALYZED. TWELVE OF THESE TRANSFUSIONS WERE COMPARED IN A PAIRED FASHION WITH FRESH, RANDOM-DONOR, POOLED PLATELETS GIVEN WITHIN A FEW DAYS TO THE SAME THROMBOCYTOPENIC RECIPIENTS. PLATELETS HAD BEEN FROZEN USING 5% DIMETHYLSULFOXIDE AS A CRYOPROTECTIVE AGENT EITHER AT A CONTROLLED RATE OF 1 K/MIN TO 193 K (1 C/MIN TO -80 C) OF A LIQUID NITROGEN FREEZER. THE MEAN FREEZE-THAW LOSS FOR THE 14 TRANSFUSIONS WAS 22% GIVING A FROZEN/FRESH RECOVERY OF 46%. THIS SUGGESTS THAT A RESERVOIR OF FROZEN PLATELETS, EITHER RANDOM-DONOR FOR EMERGENCY TRANSFUSION OR OF KNOWN HLA-TYPE FOR TRANSFUSION TO ALLOIMMUNIZED PATIENTS, CAN BE ESTABLISHED AND STORED FOR AT LEAST 3 YR.

Details

  • Original title: SUCCESSFUL TRANSFUSION OF PLATELETS CRYOPRESERVED FOR MORE THAN 3 YEARS.
  • Record ID : 1981-0291
  • Languages: English
  • Source: Blood - vol. 54 - n. 5
  • Publication date: 1979
  • Document available for consultation in the library of the IIR headquarters only.

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