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Human platelets loaded with trehalose survive freeze-drying.

Author(s) : WOLKERS W. F., WALKER N. J., TABLIN F., et al.

Type of article: Article

Summary

In the US, human blood platelets are stored in blood banks for 5 days, after which they are discarded, by federal regulation. This short lifetime has led to a chronic shortage of platelets, that is particularly acute in immunosuppressed patients, such as those with AIDS. The authors report that platelets can be preserved by freeze-drying with trehalose and suggest that these findings will obviate the storage problem. Analysis by Fourier transform infrared spectroscopy demonstrated that the membrane and protein components of trehalose-loaded platelets after freeze-drying, prehydration, and rehydration were remarkably similar to those of fresh platelets.

Details

  • Original title: Human platelets loaded with trehalose survive freeze-drying.
  • Record ID : 2002-1640
  • Languages: English
  • Source: Cryobiology - vol. 42 - n. 2
  • Publication date: 2001/03

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