LONG-TERM NORMOGLYCEMIA IN PANCREATECTOMIZED DOGS TRANSPLANTED WITH FROZEN-THAWED PANCREATIC ISLETS.

Author(s) : KNETEMAN N. M., RAJOTTE R. V., WARNOCK G. L.

Type of article: Article

Summary

THE AUTHORS REPORT SUCCESS ON LONG-TERM FOLLOW-UP WITH AUTOTRANSPLANTATION OF FROZEN-THAWED CANINE PANCREATIC FRAGMENTS. CRYOPRESERVATION WAS BY DMSO EQUILIBRATION, COOLING AT 0.25 K/MIN TO 198 K (-75 DEG C), STORAGE IN LIQUID N2 AND THAWING AT 3.5 K/MIN. FOUR OF FIVE ACUTELY AUTOTRANSPLANTED DOGS REMAINED NORMOGLYCEMIC FOR 20 MONTHS. CRYOPRESERVATION PRESERVED VIABILITY OF SUFFICIENT CANINE PANCREATIC ISLETS TO REVERSE DIABETES WITH AUTOTRANSPLANTATION.

Details

  • Original title: LONG-TERM NORMOGLYCEMIA IN PANCREATECTOMIZED DOGS TRANSPLANTED WITH FROZEN-THAWED PANCREATIC ISLETS.
  • Record ID : 1987-0764
  • Languages: English
  • Source: Cryobiology - vol. 23 - n. 3
  • Publication date: 1986

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