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PHASE TRANSITIONS IN FROZEN ANTIBIOTIC SOLUTIONS.

Author(s) : DELUCA P. P.

Summary

WHEN ANTIBIOTIC SOLUTIONS HAVE BEEN FROZEN AND MAINTAINED BELOW THE GLASS TRANSITION TEMPERATURE, THE SOLUTE REMAINS IN THE AMORPHOUS FORM. ON THE OTHER HAND, IF THEY EXHIBIT AN EXOTHERMAL CRYSTALLIZATION, THE TRANSITION TO THE CRYSTALLINE FORM IS OBTAINED BY A THERMAL TREATMENT ABOVE THE GLASS TRANSITION TEMPERATURE. GLASS TRANSITIONS OCCUR AT 208, 253 AND 263 K (-65, -20 AND -10 DEG C),AND EXOTHERMS ARE OBSERVED AT 243, 263 AND 268 K (-30, -10 AND -5 DEG C) RESPECTIVELY FOR MANNITOL, CEFAZOLIN SODIUM AND NAFCILLIN SODIUM. THE PHASE TRANSITIONS OCCURRING IN THE FROZEN SOLUTIONS OF SELECTED COMPOUNDS WERE IDENTIFIED AND A RELATIONSHIP WAS ESTABLISHED BETWEEN THE PHASES AND THE PROBLEMS OBSERVED IN THE STORAGE OF FROZEN SOLUTIONS AND IN THE FREEZE-DRYING PROCESS.

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Pages: 1985-1

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Details

  • Original title: PHASE TRANSITIONS IN FROZEN ANTIBIOTIC SOLUTIONS.
  • Record ID : 1987-0779
  • Languages: English
  • Source: Fundamentals and Applications of Freeze-Drying to Biological Materials, Drugs and Foodstuffs.
  • Publication date: 1985/05/20
  • Document available for consultation in the library of the IIR headquarters only.

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