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Simulation of the micro-scale interaction between ice and biological cells.

Author(s) : MAO L., UDAYKUMAR H. S., KARLSSON J. O. M.

Type of article: Article

Summary

The paper presents numerical simulations of the response of a biological cell during freezing. The cell is modelled as an aqueous salt solution surrounded by a semi-permeable membrane. The concentration and temperature fields both inside and outside a single cell are computed taking into account heat transfer, mass diffusion, membrane transport, and evolution of the solidification front. The external ice front is computed for both stable and unstable growth modes. For the cooling conditions, solute and cell property parameters used, the low Peclet regime applies. The computational results are therefore validated against the conventional membrane-limited transport (Mazur) model. A spatially non-isothermal situation is also considered and shown to yield significant differences in the cell response in comparison to the isothermal case.

Details

  • Original title: Simulation of the micro-scale interaction between ice and biological cells.
  • Record ID : 2004-0898
  • Languages: English
  • Source: International Journal of Heat and Mass Transfer - vol. 46 - n. 26
  • Publication date: 2003/12

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