AN IRREVERSIBLE THERMODYNAMIC ANALYSIS OF CELL FREEZING IN THE PRESENCE OF MEMBRANE PERMEABLE ADDITIVES. NUMERICAL MODEL AND TRANSIENT CELL VOLUME DATA.

Type of article: Article

Summary

MASS TRANSPORT OF WATER AND A PENETRATING CRYOPHYLACTIC ADDITIVE DURING FREEZING IS SIMULATED BY A KINETIC MODEL BASED ON THE PRINCIPLES OF IRREVERSIBLE THERMODYNAMICS. INDEPENDENT PARAMETERS IN THE MODEL INCLUDE THE SPECIMEN TEMPERATURE AND COOLING RATE, THE INITIAL ADDITIVE COMPOSITION AND CONCENTRATION, AND THE MEMBRANE WATER AND ADDITIVE PERMEABILITIES AND REFLECTION COEFFICIENT. FLUX EQUATIONS ARE DERIVED FOR THE SIMULTANEOUS TRANSPORT OF BOTH WATER AND ADDITIVE, AND ARE SOLVED TO OBTAIN VALUES FOR THE TRANSIENT CELL SOLUTION VOLUME DURING FREEZING.

Details

Original title: AN IRREVERSIBLE THERMODYNAMIC ANALYSIS OF CELL FREEZING IN THE PRESENCE OF MEMBRANE PERMEABLE ADDITIVES. NUMERICAL MODEL AND TRANSIENT CELL VOLUME DATA.
Record ID : 1984-2470
Languages: English
Source: Cryo-Letters - vol. 4 - n. 5
Publication date: 1983
Document available for consultation in the library of the IIR headquarters only.

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Indexing

Themes: The influence of refrigeration on cells, tissues and organs
Keywords: Thermodynamics; Cryoprotectant; Cooling rate; Cell; Calculation; Mass transfer; Heat transfer; Permeability; Membrane; Cryopreservation; Freezing