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THE EFFECT OF ICE FORMATION ON THE FUNCTION OF SMOOTH MUSCLE TISSUE STORED AT 252 OR 213 K (-21 OR -60 DEG C).

Author(s) : TAYLOR M. J., PEGG D. E.

Type of article: Article

Summary

IT WAS SHOWN THAT EXPOSURE OF MAMMALIAN SMOOTH MUSCLE TO 252 K AND THE INCREASED CONCENTRATION OF SOLUTES HAD LITTLE EFFECT ON THE CONTRACTILE RECOVERY OF THE MUSCLES, WHEREAS ICE FORMATION WAS DAMAGING. FURTHERMORE, THE RATE OF COOLING HAD A MARKED EFFECT UPON FUNCTIONAL RECOVERY IN THE FROZEN MUSCLES, AND THIS COULD BE CORRELATED WITH THE KNOWN EFFECT OF THESE COOLING RATES ON THE PATTERN OF ICE FORMATION IN THE TISSUE. THE EFFECT WAS ALSO SEEN IN MUSCLES FROZEN AT 213 K. IMPROVED BUFFERING INCREASED THE FUNCTIONAL RECOVERY OF ALL GROUPS, BUT THE EFFECT OF ICE, AND OF COOLING RATE IN THE PRESENCE OF ICE, WAS CONFIRMED. THESE FINDINGS MAY HAVE SIGNIFICANT IMPLICATIONS FOR ATTEMPTS TO CRYOPRESERVE COMPLEX TISSUES AND ORGANS.

Details

  • Original title: THE EFFECT OF ICE FORMATION ON THE FUNCTION OF SMOOTH MUSCLE TISSUE STORED AT 252 OR 213 K (-21 OR -60 DEG C).
  • Record ID : 1983-1998
  • Languages: English
  • Source: Cryobiology - vol. 20 - n. 1
  • Publication date: 1983

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