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THERAPEUTIC EFFECTIVENESS OF FROZEN PLATELET CONCENTRATES FOR TRANSFUSION.

Author(s) : LAZARUS H. M.

Type of article: Article

Summary

SIX PATIENTS RECEIVED PLATELET CONCENTRATE TRANSFUSIONS FROM THEIR HLA-IDENTICAL SIBLINGS. PLATELET CONCENTRATES WERE ADMINISTERED EITHER FRESH, OR AFTER BEING FROZEN IN 10% DIMETHYLSULFOXIDE, AT A SLOW CONTROLLED RATE (1 K / MIN (1.C/ MIN)) OR RAPIDLY (ABOUT 8 K / MIN (8.C / MIN)) IN VAPOR-PHASE OF A LIQUID NITROGEN REFRIGERATOR. THE MEDIAN FREEZE-THAW LOSS WAS 13. 5%. THE MEAN 1-HR AND 20-HR CORRECTED INCREMENTS IN PLATELET COUNT WERE CALCULATED FOR FRESH PLATELET CONCENTRATES TRANSFUSED BEFORE AND AFTER TRANSFUSION WITH CONTROLLED-RATE FROZEN AND VAPOR-PHASE FROZEN PLATELET CONCENTRATES. THERE WAS NO SIGNIFICANT DIFFERENCE AMONG THE FIRST AND SECOND TRANSFUSION OF FRESH PLATELET CONCENTRATES, NOR WAS THE DIFFERENCE OBSERVED BETWEEN FRESH AND CONTROLLED-RATE FROZEN PLATELET CONCENTRATES SIGNIFICANT. THE DIFFERENCE BETWEEN FRESH AND VAPOR-PHASE FROZEN PLATELET CONCENTRATES, AND BETWEEN CONTROLLED-RATE FROZEN AND VAPOR-PHASE FROZEN PLATELET CONCENTRATES WERE HIGHLY SIGNIFICANT.

Details

  • Original title: THERAPEUTIC EFFECTIVENESS OF FROZEN PLATELET CONCENTRATES FOR TRANSFUSION.
  • Record ID : 1982-0299
  • Languages: English
  • Source: Blood - vol. 57 - n. 2
  • Publication date: 1981
  • Document available for consultation in the library of the IIR headquarters only.

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