Cooling and freezing damage platelet membrane integrity.

Author(s) : REID T. J., LARUSSA V. F., ESTEBAN G., et al.

Summary

This study investigated the interaction between the platelet cytoskeleton and membrane during storage at 4 °C for 1-21 days, using EGTA/AM and cytochalasin B as platelet protectants. Treated platelets showed a gradual loss of membrane integrity reaching a maximum at 7 days. Untreated platelets had complete loss of integrity and function after 1 day of storage.

Details

  • Original title: Cooling and freezing damage platelet membrane integrity.
  • Record ID : 2000-2803
  • Languages: English
  • Publication date: 1999/05
  • Source: Source: Cryobiology/Soc. Cryobiol., Annu. Meet., Pittsburgh/Symp. Cryopreserv. human Platelets, Pittsburgh
    vol. 38; n. 3; 209-224; 7 fig.; 1 tabl.; 10 ref.