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Effective freeze-drying: a combination of physics, chemistry, engineering and economics.

Author(s) : FRANKS F.

Type of article: Periodical article

Summary

Current stabilisation strategies for purified biochemical and biological products in particular freeze-drying are reviewed and discussed. This is followed by the physics and chemistry of freezing and a discussion of the properties of glassy materials. The factors affecting primary and secondary drying are then considered together with product stability in the dried state. The author concludes that successful freeze-drying depends on a complex interplay between many factors, some of which are within the control of the processor. Glass transition is central to the process and is determined by product composition which also affects its subsequent stability and shelf life. G.R.S.

Details

  • Original title: Effective freeze-drying: a combination of physics, chemistry, engineering and economics.
  • Record ID : 1996-3762
  • Languages: English
  • Source: Inst. Refrig., Adv. Proof - 6 p.; 4 fig.; 13 ref.
  • Publication date: 1994/12/01
  • Document available for consultation in the library of the IIR headquarters only.

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