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NETWORK THERMODYNAMIC MODELLING WITH BOND GRAPHS FOR MEMBRANE TRANSPORT DURING CELL FREEZING PROCEDURES.

Author(s) : DILLER K. R.

Type of article: Article

Summary

FREEZING PROCEDURES FOR PRESERVATION OF LIVING CELLS CREATE OSMOTIC STRESSES ASSOCIATED WITH THE ADDITION AND REMOVAL OF CRYOPROTECTIVE AGENTS AND WITH ICE FORMATION IN THE EXTRACELLULAR SOLUTION, CAUSING A CONCOMITANT SEGREGATION OF ELECTROLYTES INTO THE REMAINING LIQUID PHASE. WHEN THESE OSMOTIC STRESSES ARE INTRODUCED, COUPLED FLOWS OF WATER AND PERMEABLE SOLUTE ARE INDUCED ACROSS THE PLASMA MEMBRANE. A NETWORK THERMODYNAMIC MODEL IS PRESENTED. THE MODEL IS A COMPLETE REPRESENTATION OF THE EQUATIONS THAT DESCRIBE THE PROCESS. DETERMINATION OF THE TRANSIENT CELL VOLUME DURING ADDITION OF GLYCEROL TO AN ERYTHROCYTE SUSPENSION IS USED TO DEMONSTRATE THE MODEL.

Details

  • Original title: NETWORK THERMODYNAMIC MODELLING WITH BOND GRAPHS FOR MEMBRANE TRANSPORT DURING CELL FREEZING PROCEDURES.
  • Record ID : 1989-2073
  • Languages: English
  • Source: J. Heat Transf. - vol. 110 - n. 4A
  • Publication date: 1988
  • Document available for consultation in the library of the IIR headquarters only.

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