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Nonmonotonic trends in electrolyte-induced injury to rapidly cooled erythrocytes.

Author(s) : BREARLEY C. A., HODGES N. A., OLLIFF C. J.

Type of article: Article

Summary

Rapid freeze-thaw injury to erythrocytes and erythrocyte ghosts has been shown to be strongly cation dependent. Injury can be reduced by the inclusion in the freezing media of saccharide cryoprotectants or by the substitution with less injurious cations. Careful choice of electrolyte species allows injury to be reduced to levels comparable to that afforded by saccharide cryoprotectants. A possible mechanism for the nonmonotonic trends in injury observed with cations in considered.

Details

  • Original title: Nonmonotonic trends in electrolyte-induced injury to rapidly cooled erythrocytes.
  • Record ID : 1993-0524
  • Languages: English
  • Source: Cryobiology - vol. 29 - n. 2
  • Publication date: 1992/04

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