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THE FREEZE-DRIED PRESERVATION OF LIPOSOME ENCAPSULATED HEMOGLOBIN: A POTENTIAL BLOOD SUBSTITUTE.

Author(s) : RUDOLPH A. S.

Type of article: Article

Summary

IN THE PAPER, THE ABILITY OF CARBOHYDRATES (TREHALOSE, SUCROSE, AND GLUCOSE) TO PRESERVE THE BLOOD SUBSTITUTE LIPOSOME-ENCAPSULATED HEMOGLOBIN (LEH) IN THE FREEZE-DRIED STATE IS EXAMINED. THE WATER-FREE STABILIZATION OF INDIVIDUAL COMPONENTS OF THIS BLOOD SUBSTITUTE AND LEH IS REPORTED. LYOPHILIZATION OF HEMOGLOBIN SOLUTIONS IN THE ABSENCE OF CARBOHYDRATES RESULTS IN SIGNIFICANT OXIDATIVE DEGRADATION OF HEMOGLOBIN. HEMOGLOBIN SAMPLES LYOPHILIZED IN INCREASING CARBOHYDRATE CONCENTRATIONS SHOW REDUCED LEVELS OF METHEMOGLOBIN. STORAGE OF LYOPHILIZED HEMOGLOBIN SAMPLES FOLLOWING REHYDRATION AT 277 K (4 DEG C) SHOWS THE SAME RATE OF METHEMOGLOBIN FORMATION REGARDLESS OF WHETHER CARBOHYDRATES ARE PRESENT.

Details

  • Original title: THE FREEZE-DRIED PRESERVATION OF LIPOSOME ENCAPSULATED HEMOGLOBIN: A POTENTIAL BLOOD SUBSTITUTE.
  • Record ID : 1989-2085
  • Languages: English
  • Source: Cryobiology - vol. 25 - n. 4
  • Publication date: 1988

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